I think we are confusing 'meaningless' with 'insignificant' or 'unimportant', the first being absolute, the others relative.

In the universe we are tiny and possibly even irrelevant, but in the cosmos it is size that is irrelevant, (if not meaningless, heh heh). In the cosmos we have meaning, purpose, and worth, not just to each other, but to and within ourselves as well.
Try saying that three times really fast.