huffy: roused to anger; "stayed huffy a good while" -Mark Twain * ; "she gets mad when you wake her up so early"; "mad at his friend"; "sore over a ...
brainsick: affected with madness or insanity; "a man who had gone mad"
delirious: marked by uncontrolled excitement or emotion; "a crowd of delirious baseball fans"; "something frantic in their gaiety"; "a mad whirl of pleasure"
harebrained: very foolish; "harebrained ideas"; "took insane risks behind the wheel"; "a completely mad scheme to build a bridge between two mountains"
-snip-
* Good ole Mark Twain. I like that "stay huffy" expression. I thought that was a new one, but I guess I was wrong.
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I suppose that the "mad" in Mad Magazine uses the second and fourth definitions of that word.
Here's some information about Mad Magazine for those who aren't familiar with this "American humor magazine founded by editor Harvey Kurtzman and publisher William Gaines in 1952 [which offers] satire on all aspects of American life and pop culture; deflates stuffed shirts and pokes fun at common frailties."
There's also a hip-hop definition of the word "Mad." In hip-hop usage "mad" "Mad" is an adjective that means "much"; "a lot of"
Here's a sentence that uses three different definitions for the word "mad":
"I have mad respect for the experiences of those early blues men and blueswomen. If I had to go through half of the changes those folks did, I'd either be real mad most of the time or I'd probably woulda ended up going stark raving mad."