My favorite has always been Todd Rundgren's "You Left Me Sore" about some sort of STD.

Love is infectious
And I was a victim
The worst case you'd ever seen
But now I know no doctor or nurse
Could cure what you gave to me

'Cause you really
You left me sore
You really left me sore now, baby
You messed me up for sure
And I don't mean maybe
'Cause you really left me sore

etc.....