When things are going wrong, I have several expressions I'm fond of...
For example, when the Cleveland Indians were in the process of allowing the Sox to score 8 runs in the bottom of the eighth, and the shortstop and third baseman ran into each other while the ball bounced over the wall for a double...what better time for "man, the wheels are really coming off now." I also like, when things are going from bad to worse, the Marty Feldman line from Young Frankenstein..."could be worse. Could be raining." I sometimes vocalize a clap of thunder at this point. I also like the old fashioned expression of concern and disappointment "fuck me", which sometimes pops out at inopportune moments. This could be one of them.