I guess it depends on your definition of 'advanced'. Yes, some early cultures made fascinating carvings, mounds and experimented with surgery 'of sorts'....but if they HAD a truly advanced civilization, we'd expect to find more that stone carvings and skulls with holes.

There is NO real hard evidence of large scale semi-technological civilizations way back beyond 20,000 years ago...merely fascinating examples of what some cultures were drawing on rocks 5,000 to 20,000 years ago.