I use Spybot, and it does a very good job of tracking any registry changes and keeping track of what actually gets to start up at startup.

This morning I went looking for software updates and I find at the Office of Information Technology office at my university that they have a variety of software available to the campus community. They've always had a few, but they're getting serious about the types of security available. I'm not the only one who works at home, and it's worth it to them to be sure that my home computer is as secure as my office computer. They have the license to use Spybot, along with one other. I suspect it is a situation where you choose one or the other. Using two programs that try to do the same thing messes up the works (ask me how I know. . .).

SRS