We may just be incredibly lucky but both my son and I run Vista and have had no problems with it. Never had a DRM issue and it runs all my software. The only issue Peter has had is drivers for a piece of Steinberg music hardware but that's mainly because Steinberg have decided not to issue Vista drivers for a lot of their older gear, presumably in the hope you'll go and buy some new stuff. Bad strategy, Peter fudged a way round the drivers and now won't buy Steinberg.

All the best

Steve