There can be side effects from Glucosamine.

I tried it a couple of times, Within a few days of starting use I was freezing cold and almost suicidally depressed. Stopped the GS - symptoms went away. Tried again about a year later, same symptoms.

Same thing happened with herbal remedies such as Devils Claw, I think it was caused.

This doesn't seem to be a common thing but, if you do find your mood changes when you're taking it, stop using it.