I started out w/duodenal ulcer, and antiobiotics did seem to kill it off. About 6 yrs later, the reflux returned w/out the ulcer.

I've never been able to tolerate the "purple pill" so was prescribed Aciphex, or rabeprazole sodium, which I take daily first thing on an empty stomach.

Adjusting your diet is still inevitable though, and probably looking at weight loss (I'm just sayin'), if that is an issue for you too. GERD is exacerbated by weight gain.

While the Aciphex has been a life saver and I can eat most things I enjoy, the real problem now is with the NSAIDS for osteoarthritis of the knee, and me being on my feet all day. And sometimes my daily red wine/beer habit is put on hold too. Alcohol can really aggravate GERD, and there are contraindications for taking GERD meds and drinking.

Sucks, don't it?