Referring to the earlier query aboutn the difference between "broken up" and "broken down": the use of "up" indicates finality, completeness, a going to the limit. So:

Relationship "broken down" = damaged but possibly repairable
A couple have "broken up" = gone their different ways
To close shop v. to close up shop/the company = the latter indicates dissolution
Bring it right up to your nose = it can go no further, "up to" shows limit