The Wheatstone layout is more standard. By that I mean that one Wheatstone is likely to be the same as another, whereas every Jeffries seems to be slightly different.

I play a Jeffries, and I have a Wheatstone box on order from Steve Dickinson. I've chosen the standard Wheatstone layout for that. If it's good enough for John K. it's good enough for me!

The bottom line is that whichever layout you use, you'll find some things you can do only on one and others that you can do only on the other.

It only makes a difference anyway if you want to do something fairly sophisticated, like playing independent parts or unusual chords or in remote keys. Whichever layout you have (even with my 39 keys!) there are limitations - part of the joy of playing any musical instrument is overcoming those limitations.

Anahata