Yes.. I got very achey hand from too much 'mousing' several years ago.
I discovered a computer program which allowed me to mostly just move the mouse, and which then clicked the mouse based on rules I set...(like how long the mouse was to wait before it 'clicked', how to do a double-click, how to disable the routine..etc.

It worked like a charm...after a little getting used to. It rested my hand and kept it from cramping.

It was called "MouseTool" this is now a payware program (and I'm not sure it's still in business...the link goes to a dead site..), but the earlier free version seems to still be out there in a couple of places....and it worked fine.

At this site they list Jeff Roush's MouseTool 3.13 (Donationware) in a zip file. I think this is the correct one. If not, I probably have the old download stored somewhere.