Legalize all drugs? No. When the FDA is allowed to do what it is supposed to do, it does an excellent job of keeping unproven and dangerous drugs off the market.

Or are you speaking of illegal narcotics, marijuana and the like? Of course they should be decriminalized - these things should be regulated, at least to the degree that alcohol is, but the current level of prohibition is ridiculous. I am (physically) pretty close to the drug peddler war that is going on along the US/Mexico border, and the only reason that thousands of people a year (no hyperbole - look it up), innocent and otherwise, are being killed is the American desire for illegal narcotics. A reason for decriminalization that I don't think was mentioned is that this is the single most significant reason for the massive overcrowding in US prisons - that is, there are many thousands of people in jail for possession, use or small sale.