One of those still-to-be-understood zones is the nature of observation and awareness. How it seems to happen that observation effects quantum-scale events is a bit of a deep mystery. Even more so is how particles and energy could be held to account for awareness at all, at any but the most shallow stimulus-response level. And S==>R is not actually awareness, although it is used as a substitute when programming mindless systems to respond to circumstances the way an aware entity might.

The universe of thought, consideration, awareness, and intentionality has not been scratched by material science. There are several reasons, one of which is that material science is by its own premises, well, material. Another reason is that the majority of consciousness in this sector of existence has been so over-whumped by physical forms and the concomitant pains and overwhelms of force that it is pretty shaky on its own feet anymore. Thus, individuals who may have inklings of telepathic ability when safe and private become frozen lumps in the face of equipment and skeptical laboratory investigators. Thirdly, the substantive differences--the qualitative differences--between thought and objects have not been accounted for in most investigative procedures. THis makes it extremely tricky to set up any method of proof.

A