Try to take in some caverns. Luray Caverns are lovely.
http://www.blueridgeparkway.org/default_1.htm

Already mentioned but I am seconding, Blue Ridge Parkway North: Rockfish Gap to Roanoke - Rockfish Gap VA Scenic Drive
http://www.allgetaways.com/view_destination.asp?destinationid=XFA130-006

Be especially careful on curvy descents if it has rained or drizzled after a long dry period.   In those conditions, the roads are slicker 'n goose shit on slate on a dewy morning. Don't ask how I know.

Too bad you aren't going in late September early October. The autumn colours are stunning.

Sigh... missing home again.