The indigenous peoples in the the Americas used tobacco as a "sacred" thing -- they didn't walk around with a pipe in their mouths, but passed the smoke communally (remind you of anything?). The Europeans gave these people alcohol and they gave the Europeans tobacco. Some in both camps got along fine without indulging or overindulging, but most who tried it didn't "Just Say No" and they provided things that have killed off many of each.

I wonder what other planets hold?