Why famous? Just ordinary won't do?
In the western plains of Canada, the smallpox came late to the Indians there. Smallpox ("a terrible epidemic," says the Dictionary of Canada) in the year 1870-1871 took many Indians. Rev. McDougall, who had a mission at Pakan, Alberta, lost his wife and a daughter, and an Indian girl adoptee. The posts at Fort Victoria (at Pakan), Carleton, and others were closed to the Indians, many died. McDougall wrote, "The strain was continuous, disease and death and danger constant." Hungry Indians were a a problem (the last buffalo hunt 1872).
Most of the White and Metis personnel at the posts or in trade or cartage had been vaccinated, cowpox or vaccinia strain.

The McDougall graves, on the North Saskatchewan River at the Fort Victoria Historical Site are within 200 yards of the little farm we had obtained there (A Hudson's Bay river lot grant for Metis employees, the original cabin there the last one left).

There are plenty of accounts of the decimation of the native population, not only during the days of 'discovery', but through the 19th c.