The one with the mike has a big advantage. Even if you don't use a mike, you are still the focus of attention and can really destroy a heckler if you are so inclined.

Jud Strunk to female heckler, "Give me a break, I wouldn't pull the mattress out from under you while you are working."

That's ok, I remember my first beer."

"That's ok, I have a retarded Sister too."