I have the 5300C on my desktop and it runs fine (and has done since I first loaded XP years ago) under XP/Pro.

The HP Page BillD linked above has the versions of the software I have installed (I've still got the downloads on my disc - sj664en.exe - that's the large driver and precision scan software file from the top of the page, sj669en.exe - that's the usb patch, since that's what I'm using;use the parallel version if that's how you've got it connected and sj700en.exe - that's the software destinations path from the bottom of the page. I installed these when I updated my system from Win98SE to XP - along with other drivers that the XP installation checkup told me would be problems after the upgrade).

So if you download them and run them the scanner should be fine.

Mick