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The U.S. is a collection of 50 sovereign states. Any state can say no to any abusive federal legislation. This isn't secessionism, it's just saying No to unlawful and/or unconstitutional dictates.

Does your state have a State Sovereignty Resolution? If not, it's pretty easy to pressure your state lawmakers into passing one.

Tenth Amendment Center

Various articles on Nullification

As your state approaches bankruptcy under the burden of unfunded federal mandates, and as more and more of your friends and family become the criminally-convicted chattel of the federal government, don't forget that you have a way to say no. At the state level. But it will take a modicum of effort on your part. You'll have to let your state rep and your state senator know that you want your state to pass a state sovereignty resolution and then begin using it to nullify abusive laws.

"Thus, the particular phraseology of the constitution of the United States confirms and strengthens the principle, supposed to be essential to all written constitutions, that a law repugnant to the constitution is void; and that courts, as well as other departments, are bound by that instrument." Marbury v. Madison, U.S. Supreme Court, 1803