SRS - I have heard lots of good things about glucosamine - I did try it, twice.

Both times, after about 3-4 days I had developed almost suicidal depression, which disappeared once I stopped taking the stuff. I don't do too well with a lot of medication - I think it may have to do with brain chemistry - but it's worth noting that that can be a side effect. I hope that it works for you, anyway. Wish I COULD use it - my knees, in particular can get quite uncomfortable nowadays.