It might be worth noting that Zuckerman hasn't "lost it all" as yet.
He recently joined the "group of wealthy pledges" who have promised to give away half their wealth to worthy causes.
Bill Gates started off with giving half of his, and has added to his contributions since. Buffet has a wide range of beneficiaries and has shown the paperwork on enough pending dispositions to account for more than half of his. The two of them kicked off the campaign and have recruited quite a number of participants.
Gates has already pretty much cornered the market on killing mosquitos, but certainly Zuck's contributions can find another pest to get rid of, or another disease to cure.
If only there could be a cure for ignorance and superstition ...