I started to write a long explanatory essay on various nsaid drugs and how they work on prostaglandins and how there are now known to be 2 kinds of prostaglandins...the joint stabber kind and the stomach- sparing kind like Celebrex, Vioxx and Arthrotek which are known as COX-2 inhibitors. I've had 2 total hip replacements.... (thank God I'm not a centipede!) My carpal tunnel wrists were operated on 2X with good results. This past winter my arthritis was awfully painful and widespread. My knees were real bad and I went., to a knee surgeon in Danbury. I received 3 injections of synthetic synovial fluid in each knee at weekly intertvals, started on arthrotek 50 mg twice daily and on Glucosamine+shark cartilage 4 tablets daily My knee pain was gone at the end of 2-3 weeks.

I am now as happy as pig in s--t. I know the knees were helped by the "synovial" fluid injections, I'm certain the glucosamine+shark cartilage has been helpful in doses of 2 daily for at lest 3 months. I think that catching the shark in these cold Block Island waters and ripping out his cartilage is also a healthy source of endogenous cortisone and epinephrine!

My advice would be to take glucosamine+chondroitin 4 daily for at least 3 months. Good luck to all, Larry Parish Arthrotek had aa profound effect on my affect arthrtek