Lefthanded Guitar -- Peep and the Big Wide World popped into my head as soon as I saw the title of this thread.

For those who don't know: It's designed as an "introduction to science for pre-schoolers"

But the humor is subtle and sophistacated. And for the interest of Mudcatters, the theme song is sung by Taj Mahal. And the incidental music is a light touch banjo.

It never fails to cheer me up.

The official website has video clips available online, here: Peep and the Big, Wide, World -- Videos