The issues Little Hawk notes are really relevant...but in today's world there are even more as kids deal with 'standards of beauty' (such as weight) and 'social media' where some tend to value themselves by numbers and types of 'friends'... and other slippery, ambiguous criteria. Even the old bullying problem has taken on new dimensions with internet/WWW harassing going on.
All the old things that worried and upset kids are still there...but with overlays that we can barely comprehend yet. Most teens today can't even imagine a time without cell phones and Facebook and the rules about 'how to behave' there are still being written and NOT really enforced.

When all this is added to the possible genetic links noted in the OP, it is really scary trying to sort out...or even become aware of... each young person's concerns.