Always choose the best key for the voice(s).

The choice of inversions is a matter of taste, but there is little doubt in my mind that root D or Dm sound better in single drop D.

The E chord always sounds a bit off if playing in A (standard tuning), sort of bluesy in stead of folky.

Playing in C the F sounds a bit rock and roll.

E always sounds like the start of a 12-bar, somehow.

So I guess that does mostly leave me with variants of D or G plus capo.

Shame F sharp suits my voice! But at least it keeps the melodeons out.