I prefer not to have a large C: drive, and install a secondary drive for data. That way, it's quick and easy to backup the system drive, but more importantly, quick and easy to restore should something go wrong.

It also means that you won't get processing bottlenecks with swapfiles and so on...

This is standard practice with servers, too.

Better still, use a network drive for backups - it always comes down to how important your data is and how easy it would be to replace it... recordings and photgraphs tend to be unique...!