I got here late as usual, but do have some experience in shooting mistletoe out of trees. Growing up in rural Virginia in a relatively large extended family our Sunday gatherings often included finding something to shoot at, a situation that was encouraged by an uncle who was a gun collector and who always had something different for us to fire. When it came to shooting down mistletoe we used a .22 and it was not unusual for it to take more than one shot. We ended up with relatively small sprigs. If I were to try to shoot mistletoe out of a tree now I would most likely aim for the branch that supported the mistletoe rather than firing into the ball itself. If one wants a sizable section of the mistletoe it might be more productive to find some way other than shooting to harvest it. A relatively good shot at the smaller branches supporting the mistletoe could bring down a sizable portion and if lucky it will fall directly to the ground and not get caught among lower branches.