Hot Lips Houlihan as Major Troi and Frank Burns as Julian.

Fonzie as Captain Picard.

How about Worf as Jed Bartlet on The West Wing?

Yeah!!! Worf for President! Yeehaw!

Frasier Crane as the Professor on Lost in Space.

Peggy and Hank Hill as Dick & Laura Petrie.

Kitty and Red from That 70s Show as Ozzie & Harriet.

Ulysses S. Grant as Don Henley. Oh... wait... that's something different entirely.........