From research article BMC.

Persons diagnosed with HIV infection had considerable excess mortality in comparison with the general population of the same age group and sex, despite wide availability of combined antiretroviral treatments. This excess mortality was largely due to deaths from AIDS-defining conditions, but other causes of death were also important, such as drug overdose or addiction, hepatic disease, non-AIDS-defining cancers, and cardiovascular disease. Excess mortality associated with HIV infection was observed in both men and women, and in persons with and without a history of injecting drug use.

Numerous studies have reported substantial reductions in mortality in HIV-infected persons after the introduction of combined antiretroviral treatments [21,22], the same as we found in Navarre [9]. Nonetheless, mortality in this group is still 14 times higher than in the general population after adjusting for sex and age group. Some studies have found somewhat lower excess mortality [23], but different results could be explained by the epidemiological characteristics of those infected, time of evolution of the infection, and whether or not persons who are not receiving antiretroviral treatment are included. Health authorities should be alert not only to those causes with relative excess mortality, but also to those that are responsible for the largest absolute number of deaths.

In the era of combined antiretroviral treatments, mortality among persons diagnosed with HIV has continued to decline, mainly in those without a history of injecting drug use [21], but is still a long way from reaching mortality levels similar to those in the general population [5].