As a domain name holder I use a lot of one-off email addresses when enquiring or purchasing.

But I still get spam from avaaz & linkedin which I deal with in Outlook > Tools > Rules. But they are generated by friends (some friend!) thinking I want to know all the latest gossip & or famine/earthquake/flood/pandemic/politics that needs my spare stipend.

& Farcebook has been dealt with on Farcebook --- as if I want to know that a friend of a friend has just looked at a picture from a friend of a friend of theirs! (geeeeeeeze).