Most people play Calliope in D. It works best in second position on a G harmonica. Playing it in E would be no problem as most self-respecting harmonica players at a session would have an A harp with them. And it's fine in E on a fiddle. If you really must. Our set goes Connaughtman's Rambles-Saddle The Pony-Calliope House (in D). Plenty of mode-change lifts in there, all doable by me on a G harp, no tyranny!