Almost anything in West Virginia.... the one I've done many times is 219 both North & South out of Elkins (Elkins is home to Davis & Elkins college, where The Augusta Heritage Center holds music workshops.) 219 runs from I-64 in the South into Elkins. Then, at Elkins one can go several ways....North, East...or even Westish...

Then, if you really want ideas, contact Charley Baum, the Getaway chairman, who is a human road map. He KNOWS almost every highway in the US, and has driven amazing numbers of them.... especially in the East.