Alcohol - the alcohols (congeners) that give the brew colour and flavour are not ethyl alcohol and the liver has a harder time digesting them or their byproducts. Hence headache sooner if you are a red-head (?) like me or hangover if you are not. Pick you dosage.

Chocolate & cheese can give some people migraine. Not me thankfully.

People differ.

But there is this well accepted theory that many toxins become detrimental above finite doses, but are holistically beneficial below that.
Think belladonna. Think vitamin C for gawd's sake!

As I try to highlight: homo sapiens evolved ever larger brains by cooking food, and that included meat that they gorged on occasionally. The gorgeousness is more frequent these days.
Huge Stan - we have a problem!