Have you tried other USB ports?
Have you tried a different mouse - borrow one?
Have you tried other USB devices in that port?
Does that mouse work in other machines?
Is the mouse disabled in the control panel device manager (get there via windows-key and X)
What does the device manager say about the mouse?

Nearly all mice are 'generic pointing devices' and Windows will have drivers. If the mouse is unusual go to its manufacturer's website - but unless it's a major brand you won't find it.

I like Trackpoints - but they take sime getting used to.