Jeri,

Hw different is it to live on the ISS than on Mars?

The ISS is in space, with no atmosphere at all around it, No natural shielding from cosmic rays or solar flares, not resources except what has been shipped up there.

Mars has an atmosphere to protect against cosmic rays, solar flares, and micro meteors. It has physical resources that can be utilized for both construction and supply.

Agreed, it does take a bit longer to get to. Months to Mars vs Hours to the ISS. This means that supplies should be sent first, so they are already in Mars orbit when needed. Not a major problem: Mars has a moon that would be more useful than the ISS for a supply dump (Deimos) and then the time to surface would be similar to the time to orbit for the ISS.