I do not think most europeans realise just how much of a discrete entity Galicia is. It is very proud of it's celtic past and the Galego language, which is widely spoken. It has had several independance organisations in existance in the recent past and should Catalonia free it's shackles I would anticipate Galicia following right behind. Even though Franco came from the area he did Galicians no favours and tried to destroy the language.
The basques have been agitating for more independence for decades.
Some interesting facts on the languages below and possible reasons for the friction with the Castilian areas of Spain.

http://scholarworks.umt.edu/cgi/viewcontent.cgi?article=2201&context=etd