I did this a couple of years ago, Joe, and really like the faster computer that resulted. I have several multiple terabyte drives inside and out (to do with photo processing, document design, and using my computer as a DVR because it has a TV receiver), but for security purposes I've always kept my programs only on the C drive and my data on other drives. I didn't have to remove much to run the Samsung software, and I don't think it took very long at all to move the data.

I keep my desktop on a different drive, all of my images on a different drive, and though there is a "Downloads" folder is on the C drive, I always redirect any downloads to a folder on my D: drive in my documents library.