I was strolling by the meat counter in a store the other day and on the shelf were packages of elk, bison, and wild boar. I suspect very strongly that they were all farmed (how can you call it "wild" boar if it's grown in a fenced area?). Bison (buffalo to us in the US) is widely farmed here, elk not so much but some and all too often for "hunters" to shoot for huge antler racks to put on their wall.

There is a thing called "Chronic Wasting Disease" (CWD) in American mule deer, whitetail deer, and elk. It is a type of TSE -- fortunately it has been stopped at the Idaho border (so far). The CDC published the following suggestion for hunters.

[a]s a precaution, hunters should avoid eating deer and elk tissues known to harbor the CWD agent (e.g., brain, spinal cord, eyes, spleen, tonsils, lymph nodes) from areas where CWD has been identified".

I've eaten a lot of venison, all well cooked muscle tissue. I don't know of anyone who eats deer tonsils or elk eyes! Brucellosis can affect buffalo (bison), which is why Montana ranchers want every buff that wanders in from Yellowstone NP killed -- they're afraid that it is endemic in the park and will infect their cattle.

There are some very limited buffalo hunts available if you have the money and are lucky enough to win a lottery for a license. American Indians can kill a buffalo or two as it is part of their culture, but even that is carefully controlled.

Gray whales have been hunted by the tribes of the Pacific Northwest and Alaska. The last time I know of that the animal was harpooned from a traditional canoe paddled by tribal members. It was given the coup de grace by shots from a Barrett Model 82A1 .50 caliber rifle. The meat was divided among the member of the tribe.