well I am guilty of most of these (except "nucular")so I guess I'm like you know the sooooooo most ignorant college grad who, like, ever lived, even though I was, like, an English major.........There's a time and place to be goofy and a time and place to be serious. I would not use casual speech in a formal presentation, nor would I use casual writing in a formal letter.
Personally, life's too short to get annoyed by goofy stuff.