Being a website with loads of audio and a few audio players, the obvious choice has been to use what has already been mostly done.

There is one limitation - that of playing an audio as soon as the page loads. Modern browsers basically expressly inhibit that.

My solution, for those familiar with JavaScript and HTML, was to trigger an event on the first key press, that then looks like the user has triggered the event, which is allowed. Not sure how functional this is as JAWS is a layer on browsers and may not pass on key presses. Mouse moves, which might have been an option, yet ineffective because JAWS obviates mouse use (that is somewhat visual after all).