Not that LSD, mescaline and psylocybin are the triumpherant of psychedelics but if I were to compare them, LSD opens every circuit in the brain simultaneously and what prevails is left to chance.
Mescaline has a definitive organic quality and psilocybin has a personal relationship with neural pathways and has a get together in the amygdala. These psychadelics generally flow the same direction down the active Associative river current but Ketamine is a dissociative and goes the other direction. Less will be remembered from the experience but some imagery and memory can be recovered from the strange sleep.

Ayehuesca has its own organic MAOI inhibitors that sustain a hallucinatory state. No one knows how ancient the unintuitive recipe is.