To get the most out of my stratocaster, I prefer the heavy-duty humbucking pickups, and the Pearson "Knuckle-buster" heavy duty strings. My best advice on amplification is to use the Krate Red Voodoo Stacks. If you've got a crowd of 10,000 or under, one stack is plenty. The 1200 watts gives me plenty of attack, sustain, and controlled feed-back. For stadium gigs where a crowd of 30000 demands the maximum in sheer power, two stacks are really plenty. Any more and you can actually maim people sitting close to the stage.As far as finding a pick-up that maintains the true sound of my guitar, well, I haven't been able to actually hear my guitar since the Van Halen 51/50 Tour in 1987.
Mas Tequila!
Sammy