Though I experiment quite alot, I always come back to the Dunlop Gatorgrips (at least that's what the shopkeep calls them), the ones with an alligator on them. Purple ones, .71mm, more or less medium weight picks. I switched to them about 10 years ago from Fender mediums. Once in a while I'll use a lighter one, but not often. That's for guitar.
I use the 1.14mm for mandolin, though I use dull point for reasons I haven't figured out yet.
I've got a box full of picks of a thousand shapes, sizes, and composition. I give alot away, but somehow they seem to breed.