Because of the arthritis and tenosynovitis in my hands, I’m running Elixir Nano PB 12s or D’Addario XS PB 12s on all my guitars now, including my HD-28V and my D-18 which I used to run with 13s.

As I always do when trying a different gauge of strings, I measured the neck-relief before dropping gauges, and again after the change. On both Dreads, the relief had lessened with the lighter strings - all it took was a (1/8-turn anti-clockwise on the TR to get it back to where I like it (~0.006”). It’s really not difficult or risky, provided you go slow and easy.

I do like to measure things - helps to keep track of action on my guitars and, if something changes, it’s a straightforward matter to determine what the change is, and how to correct it. I know that my actions are all 3/32” - 2/32” at the 12th fret, and ~0.006” relief. If something begins to feel ‘wrong’, I know where my aiming points should be, and what I need to do to hit the target.

IMHO, and YMMV of course!