In Issac Newton's time, things were mechanical, so his clever thinking involved mechanical theories. By the time steam engines came along, physics dealt with thermodynamics, and nowthis information age deals with bits and quantum qubits,
How small is the quantum? If you made a proton the size of the Earth, the Planck scale would be the size of an atom in comparison to the Earth-sized proton.
In our time, I see a universe expanding at an acceleration at the horizon similar to the acceleration of matter falling into a black hole horizon. There are coincidences that make the surface area of a black hole suggest a holographic universe, just as MOND symmetry suggests a balanced universe. To me, there are laws that make things like energy and mass equivalent, as well as energy and space are equivalent deep inside a black hole. Since we can't go there or see the Planck scale, it is likely we will never know the theory of everything, but naysayers have been wrong before.