I love open tunings on my 12, it really sings out.I just have to be prepared to do them by going through a medley of songs that use increasing numbers of dropped strings.Then,when finished,I will set itdown and play on my 6 for a while,eventually taking a break and retuning the 12.There are a lot of songs that I do on the 12 with it dropped a full step that fit my vocal range better than capoing my 6 string.
The biggest problems I have had relate to carpal tunnel syndrome as my left hand goes numb when chording the 12.
rr