This is a toughie. If they were guys you could privately tell them to keep quiet, you are a pain in the a**, but the different gender involved here means you could be open to a complaint of harassment.
Best thing to do is to document every incident and in particular document every time you go to your supervisor with a complaint. Encourage your other co-workers to do likewise. And if you do confront the loudmouths, do so with absolute politeness and cordiality. And DOCUMENT everything you say and their responses.
Really. Write it down and make a record. Its for your own self protection.
Good Luck
Mark