I use Outlook Express, and in two years I've only been targeted four times. That was within a few days and all four attempts came from the same source -- my wife's cousin's home computer. My wife Barbara's cousin Janice works at the local university, and the university's computers were infected. Janice managed to infect her home computer by e-mailing her husband. Once they knew about it, they got the university's resident exorcist to come out and get rid of it.It attacked our computer when Janice e-mailed Barbara (before she even knew she had a virus), but Norton Antiviris identified it (Kakworm) coming down the wire, put it into a "quarantine" file, and splashed a big, red warning across the screen. All we had to do was pull up Norton Antivirus and delete the quarantined file. No sweat.
Be sure you have a good antivirus program and update it frequently. I do mine every week.
Don Firth