I know some of these have been this way before, but they're irresistible. Don't let the bozone layer get in your way...

Intaxication: Euphoria at getting a tax refund, which lasts until you realize it was your money to start with.

Reintarnation: Coming back to life as a hillbilly.

Bozone: (n.) The substance surrounding stupid people that stops bright ideas from penetrating. The bozone layer, unfortunately, shows little sign of breaking down in the near future.

Foreploy: Any misrepresentation about yourself for the purpose of getting laid.

Cashtration: (n.) The act of buying a house, which renders the subject financially impotent for an indefinite period.

Giraffiti: Vandalism spray-painted very, very, high.

Sarchasm: The gulf between the author of sarcastic wit and the person who doesn't get it.

Inoculatte: To take coffee intravenously when you are running late.

Hipatitis: Terminal coolness.

Osteopornosis: A degenerate disease. (This one got extra credit).

Karmageddon: It's like, when everybody is, like, sending off all these really bad vibes, right? and then, like, the Earth explodes and it's like, a totally serious bummer.

Decaflon: (n.) The grueling event of getting through the day consuming only things that are good for you.

Glibido: All talk and no action.

Dopeler effect: The tendency of stupid ideas to seem smarter when they come at you rapidly.

Arachnoleptic fit: (n.) The frantic dance performed just after you've accidentally walked through a spider web.

Beelzebug: (n.) Satan in the form of a mosquito that gets into your bedroom at 3 in the morning and cannot be cast out.

Caterpallor: (n.) The color you turn after finding half a grub in the fruit you're eating.

And the pick of the literature:

Ignoranus: A person who's both stupid and an asshole

Still more:

Citiot - An ignoranus in the city government who does not have a clue.

Imprecipice - A steep overhanging cliff from which one can see a beautiful view.